Frontiers in Neuroscience seminar: Measuring prevention - biomarker outcomes in clinical trials of preclinical AD

Welcome to a Frontiers in Neuroscience talk by Professor Dave Cash, University College London, UK

Lecture title: Measuring prevention - biomarker outcomes in clinical trials of preclinical AD

Lecture host: Niklas Mattsson-Carlgren

About the speaker:
David Cash is a Professor at the UCL Queen Square Institute of Neurology and an Alzheimer’s Society Dementia Research Leaders Fellow. He holds a bachelor’s degree in Biomedical and Electrical Engineering from Duke University and an MS and PhD in Biomedical Engineering from Vanderbilt University.

In addition to his academic experience, he has also spent time in industry. Professor Cash spent five years at IXICO Ltd, where he led imaging acquisition and analysis for multinational clinical trials in Alzheimer’s disease and oncology in collaboration with pharmaceutical sponsors. He now serves as a consultant to Perceptive Imaging, one of the worlds largest imaging contract research organisations, which has a focus on clinical trials in Alzheimer’s disease and Parkinson’s disease. 

His research focuses on the development and application of imaging biomarkers to detect and track the pre-symptomatic stages of dementia, and on optimising the use of imaging in large-scale, multi-site observational studies and clinical trials. He plays a key role in the design, acquisition, and analysis of major UCL-led studies, including Insight 46—the neuroimaging substudy of the 1946 British Birth Cohort—and the GENetic Frontotemporal Initiative (GENFI).

Professor Cash also contributes to several national and international imaging initiatives, including the imaging core of the Dominantly Inherited Alzheimer Network (DIAN), the MRI core of the Alzheimer’s Disease Neuroimaging Initiative (ADNI), the ISTAART Neuroimaging PIA, and the ISTAART Advisory Council. In addition to his research activities, he leads innovative training programmes, including Health and Bioscience IDEAS, a UK Research and Innovation–funded initiative developing interactive, hands-on approaches to improve researchers’ use of medical imaging data.